Acylative Kinetic Resolution of Alcohols Using a Recyclable Polymer-Supported Isothiourea Catalyst in Batch and Flow
نویسندگان
چکیده
منابع مشابه
Isothiourea-Catalysed Acylative Kinetic Resolution of Aryl-Alkenyl (sp2 vs. sp2 ) Substituted Secondary Alcohols.
The non-enzymatic acylative kinetic resolution of challenging aryl-alkenyl (sp2 vs. sp2 ) substituted secondary alcohols is described, with effective enantiodiscrimination achieved using the isothiourea organocatalyst HyperBTM (1 mol %) and isobutyric anhydride. The kinetic resolution of a wide range of aryl-alkenyl substituted alcohols has been evaluated, with either electron-rich or naphthyl ...
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متن کاملStudies towards the N-acylative Kinetic Resolution of Nobin
2-Amino-2′-hydroxy-1,1′-binaphthyl [NOBIN (1); Fig. 1] was first prepared as a racemate by Kočovský in 1991 via oxidative coupling of 2-naphthol and 2-naphthylamine in MeOH using stoichiometric tert-butylamine/ copper(II) chloride1–3. Subsequently, a variant employing aqueous iron(III) chloride was reported4,5, and (±)-NOBIN has been prepared from (±)-BINOL (3; Fig. 1) by a Bucherer reaction6. ...
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ژورنال
عنوان ژورنال: ACS Catalysis
سال: 2018
ISSN: 2155-5435,2155-5435
DOI: 10.1021/acscatal.7b04001